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Antiproliferative agent-16

Names

[ CAS No. ]:
15641-17-5

[ Name ]:
Antiproliferative agent-16

[Synonym ]:
MFCD00412076
N'-[(E)-1H-Indol-3-ylmethylene]-2-phenylacetohydrazide
Benzeneacetic acid, 2-[(1E)-1H-indol-3-ylmethylene]hydrazide

Biological Activity

[Description]:

Antiproliferative agent-16 is an indolyl hydrazide-hydrazone compound with anticancer activity. Antiproliferative agent-16 exhibits specificity toward breast cancer cells (IC50 of 6.94 μM for MCF-7 cells)[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[In Vitro]

Antiproliferative agent-16 (compound 18f) 显示出对 DU145、LnCaP、MDA-MB231、MCF7 和 PaCa2 癌细胞的细胞毒性，IC50 值分别为 115.1 μM、51.63 μM、300.8 μM、6.94 μM、和 91.18 μM[1]。

[References]

[1]. Swapna Sundaree, et al. Synthesis and anticancer activity study of indolyl hydrazide-hydrazones. Med Chem Res 25, 941-950 (2016).

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Molecular Formula ]:
C17H15N3O

[ Molecular Weight ]:
277.32

[ Exact Mass ]:
277.121521

[ LogP ]:
3.68

[ Index of Refraction ]:
1.636

Related Compounds