FSCPX

Names

[ Name ]:
FSCPX

[Synonym ]:
Lopac-F-7927
HMS3261F15
FSCPX
FSCPX xanthine
8-Cyclopentyl-N3-[3-(4-(fluorosulfonyl)benzoyloxy)propyl]-N1-propylxanthine

Biological Activity

[Description]:

FSCPX is a potent and selective irreversible antagonist of A1 adenosine receptor (A1AR), with low nanomolar potency for binding to the A1AR. FSCPX could modifies the effect of NBTI, a nucleoside transport inhibitor, by reducing the interstitial adenosine level in the guinea pig atrium[1][2].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor

[Target]

A1AR[1]

[In Vitro]

FSCPX irreversibly blocks the binding of [3H]-8-cyclopentyl-1,3dipropylxanthine ([3H]DPCPX), with an IC50 of 11.8±3.2 nM in DDT1 MF2 cells[1].

[References]

[1]. Beauglehole AR, et, al. New irreversible adenosine A(1) antagonists based on FSCPX. Bioorg Med Chem Lett. 2002 Nov 4; 12(21): 3179-82.

[2]. Erdei T, et, al. FSCPX, a Chemical Widely Used as an Irreversible A₁ Adenosine Receptor Antagonist, Modifies the Effect of NBTI, a Nucleoside Transport Inhibitor, by Reducing the Interstitial Adenosine Level in the Guinea Pig Atrium. Molecules. 2018 Aug 30; 23(9):2186.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₂₇FN₄O₆S

[ Molecular Weight ]:
506.54700

[ Exact Mass ]:
506.16400

[ PSA ]:
141.50000

[ LogP ]:
3.94000

[ Vapour Pressure ]:
3.28E-21mmHg at 25°C

Safety Information

[ Safety Phrases ]:
22-24/25