5,5'-(Diazene-1,2-diyl)bis(2-hydroxybenzoic acid)

Names

[ Name ]:
5,5'-(Diazene-1,2-diyl)bis(2-hydroxybenzoic acid)

[Synonym ]:
Olsalazine
5,5'-azosalicylic acid
Azodisal
Olsalazina
Olsalazinum [Latin]
3,3'-Azobis(6-hydroxybenzoic acid)
6,6'-Dihydroxy-3,3'-azo-di-benzoesaeure
5,5'-Azobis(salicylic acid)
6,6'-dihydroxy-3,3'-azo-di-benzoic acid
Eriochromflavin-A
C.I. Mordant Yellow 5
Dipentum
Olsalazinum
MFCD00602469
5-[(2Z)-2-(3-carboxy-4-oxocyclohexa-2,5-dien-1-ylidene)hydrazinyl]-2-hydroxybenzoic acid
Rasal

Biological Activity

[Description]:

Olsalazine is a potent inhibitor of macrophages chemotaxis to LTB4 with an IC50 value of 0.39 mM, also reduces the synthesis of 5-hydroxyeicosatetraenoic acid (5-HETE), 11-HETE, 12-HETE, and 15-HETE in polymorphonuclear leukocyte (PMNL) and mononuclear cells (MNL). Olsalazine can be used for researching ulcerative colitis. Anti-inflammatory activity[1][2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Leukotriene Receptor

Research Areas >> Inflammation/Immunology

[Target]

IC50: 0.39 mM (LTB4)[1]

[References]

[1]. Nielsen, O.H., H.W. Verspaget, and J. Elmgreen, Inhibition of intestinal macrophage chemotaxis to leukotriene B4 by sulphasalazine, olsalazine, and 5-aminosalicylic acid. Aliment Pharmacol Ther, 1988. 2(3): p. 203-11.

[2]. Horn H, et al. Modulation of arachidonic acid metabolism by olsalazine and other aminosalicylates in leukocytes. Scand J Gastroenterol. 1991 Aug;26(8):867-79.

Chemical & Physical Properties

[ Density]:
1.55g/cm3

[ Boiling Point ]:
653.233ºC at 760 mmHg

[ Molecular Formula ]:
C₁₄H₁₀N₂O₆

[ Molecular Weight ]:
302.23900

[ Flash Point ]:
348.863ºC

[ Exact Mass ]:
302.05400

[ PSA ]:
139.78000

[ LogP ]:
2.90960

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.678

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DG3482500

CHEMICAL NAME :: Benzoic acid, 3,3'-azobis(6-hydroxy-

CAS REGISTRY NUMBER :: 15722-48-2

LAST UPDATED :: 199807

DATA ITEMS CITED :: 1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 1714 mg/kg/34W-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - interstitial nephritis

REFERENCE :: AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1- 1946- Volume(issue)/page/year: 100,238,1996

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2927000090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2927000090

[ Summary ]:
2927000090 other diazo-, azo- or azoxy-compounds。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%