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Bromo-PEG1-CH2-Boc

Names

[ CAS No. ]:
157759-50-7

[ Name ]:
Bromo-PEG1-CH2-Boc

[Synonym ]:
Acetic acid, 2-(2-bromoethoxy)-, 1,1-dimethylethyl ester
2-Methyl-2-propanyl (2-bromoethoxy)acetate
MFCD28122952

Biological Activity

[Description]:

Bromo-PEG1-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Alkyl/ether


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
268.1±15.0 °C at 760 mmHg

[ Molecular Formula ]:
C8H15BrO3

[ Molecular Weight ]:
239.107

[ Flash Point ]:
115.9±20.4 °C

[ Exact Mass ]:
238.020447

[ LogP ]:
2.43

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.460

Related Compounds