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α-Helical CRF (12-41) trifluoroacetate salt

Names

[ CAS No. ]:
158535-55-8

[ Name ]:
α-Helical CRF (12-41) trifluoroacetate salt

[Synonym ]:
L-Alaninamide, L-phenylalanyl-L-histidyl-L-leucyl-L-leucyl-L-arginyl-L-α-glutamyl-L-methionyl-L-leucyl-L-α-glutamyl-L-methionyl-L-alanyl-L-lysyl-L-alanyl-L-α-glutamyl-L-glutaminyl-L-α- &#xA;glutamyl-L-alanyl-L-α-glutamyl-L-glutaminyl-L-alanyl-L-alanyl-L-leucyl-L-asparaginyl-L-arginyl-L-leucyl-L-leucyl-L-leucyl-L-α-glutamyl-L-α-glutamyl-
L-Phenylalanyl-L-histidyl-L-leucyl-L-leucyl-L-arginyl-L-α-glutamyl-L-methionyl-L-leucyl-L-α-glutamyl-L-methionyl-L-alanyl-L-lysyl-L-alanyl-L-α-glutamyl-L-glutaminyl-L-α-glutamyl-L-alan &#xA;yl-L-α-glutamyl-L-glutaminyl-L-alanyl-L-alanyl-L-leucyl-L-asparaginyl-L-arginyl-L-leucyl-L-leucyl-L-leucyl-L-α-glutamyl-L-α-glutamyl-L-alaninamide

Biological Activity

[Description]:

a-Helical Corticotropin Releasing Factor (12-41) is a 30 amino acids long, α-helical analogue of corticotropin releasing factor/hormone. Corticotropin releasing factor (CRF) is a hypothalamic hormone, which stimulates the secretion of adrenocorticotrophic hormone (ACTH). a-Helical Corticotropin Releasing Factor (12-41) would suppress the stimulatory effect[1][2].

[Related Catalog]:

Research Areas >> Endocrinology
Signaling Pathways >> GPCR/G Protein >> CRFR

[In Vitro]

a-Helical Corticotropin Releasing Factor (0.3 nM; 5-min pulses every 40 min alternately) shows the inhibitory effect on stimulated release of immunoreactive ACTH from perifused equine anterior pituitary cells in vitro.[2]. a-Helical Corticotropin Releasing Factor (0.5-5 μM) suppresses CRH-induced ACTH secretion[2].

[In Vivo]

a-Helical Corticotropin Releasing Factor (12-41) (15-150 μg; s.c.; isolated for 30 or 60 min) suppresses the active behavioral response characteristic of guinea pig pups to brief isolation in novel surroundings[1]. Animal Model: Guinea pig pups (20-26 days old and )[1] Dosage: 15, 50, 150 μg per animal Administration: Subcutaneous injection; isolated in novel surroundings for 30 min or 60 min. Result: Resulted pups vocalized more and exhibited more locomotor activity in 20- to 26-day-old pups. Increased levels of vocalizing in isolated 4- to 6-day-old pups at 50 μg dose, though no changes were seen in locomotor activity.

[References]

[1]. Hennessy MB, et al. Evidence that endogenous corticotropin-releasing factor suppresses behavioral responses of guinea pig pups to brief isolation in novel surroundings. Dev Psychobiol. 1997 Jul;31(1):39-47.

[2]. Ellis M J, et al. The effects of corticotrophin-releasing hormone, arginine vasopressin and their antagonists on ACTH release from perifused horse anterior pituitary cells[J]. Journal of endocrinology, 1994, 143(1): 85-93.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Molecular Formula ]:
C152H251N43O47S2

[ Molecular Weight ]:
3497.009

[ Exact Mass ]:
3494.801514

[ LogP ]:
-5.94

[ Index of Refraction ]:
1.644

Related Compounds