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Frovatriptan

Names

[ CAS No. ]:
158747-02-5

[ Name ]:
Frovatriptan

[Synonym ]:
Frovatriptan (INN)
Auradol
Frova
Frovelan
Miguard
Rilamig
UNII-H82Q2D5WA7
Migard
Allegro

Biological Activity

[Description]:

Frovatriptan is a potent 5-HT1B//D receptor agonist and has the highest 5-HT1B potency in the triptan class. Frovatriptan is apparently cerebroselective. Frovatriptan is efficacious and even superior in some endpoints also when taken during the headache phase in migraine attacks with aura[1].

[Related Catalog]:

Research Areas >> Neurological Disease
Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor
Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

[References]

[1]. Stefan Evers, et al. Efficacy of frovatriptan as compared to other triptans in migraine with aura.

Chemical & Physical Properties

[ Density]:
1.27g/cm3

[ Boiling Point ]:
515.2ºC at 760mmHg

[ Molecular Formula ]:
C14H17N3O

[ Molecular Weight ]:
243.30

[ Flash Point ]:
265.4ºC

[ Exact Mass ]:
243.13700

[ PSA ]:
71.90000

[ LogP ]:
2.61860

[ Vapour Pressure ]:
1.01E-10mmHg at 25°C

[ Index of Refraction ]:
1.667

Related Compounds