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APC 366

Names

[ CAS No. ]:
158921-85-8

[ Name ]:
APC 366

[Synonym ]:
L-Prolinamide, N5-(diaminomethylene)-N2-[(1-hydroxy-2-naphthalenyl)carbonyl]-L-ornithyl-
N5-(Diaminomethylene)-N2-(1-hydroxy-2-naphthoyl)-L-ornithyl-L-prolinamide
N2-[(1-hydroxynaphthalen-2-yl)carbonyl]-L-arginyl-L-prolinamide

Biological Activity

[Description]:

APC 366 is a selective inhibitor of mast cell tryptase (Ki=7.1 μM). APC 366 inhibits antigen-induced early asthmatic response (EAR), late asthmatic response (LAR), and bronchial hyperresponsiveness (BHR) in a sheep model of allergic asthma[1][2].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Ser/Thr Protease
Research Areas >> Inflammation/Immunology

[References]

[1]. Barrios VE, et al. Tryptase mediates hyperresponsiveness in isolated guinea pig bronchi. Life Sci. 1998;63(26):2295-2303.

[2]. Krishna MT, et al. Inhibition of mast cell tryptase by inhaled APC 366 attenuates allergen-induced late-phase airway obstruction in asthma. J Allergy Clin Immunol. 2001;107(6):1039-1045.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Molecular Formula ]:
C22H28N6O4

[ Molecular Weight ]:
440.496

[ Exact Mass ]:
440.217194

[ LogP ]:
0.92

[ Index of Refraction ]:
1.695

Related Compounds