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Cariporide Mesylate

Names

[ CAS No. ]:
159138-81-5

[ Name ]:
Cariporide Mesylate

[Synonym ]:
4-isopropyl-3-methylsulfonylbenzoylguanidine methanesulfonate
Cariporide mesylate
Cariporide mesilate
Cariporide mesylate (USAN)

Biological Activity

[Description]:

Cariporide is a Na+/H+ Exchanger 1 (NHE-1) inhibitor. Cariporide inhibits the expression of monocyte endothelial cell adhesion and intercellular adhesion molecule-1 (ICAM-1) mediated by high glucose (HG) by inhibiting the activation of NHE-1[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel
Research Areas >> Cardiovascular Disease
Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[References]

[1]. Wang SX, et al. Cariporide inhibits high glucose-mediated adhesion of monocyte-endothelial cell and expression of intercellular adhesion molecule-1. Life Sci. 2006 Aug 29;79(14):1399-404.  

Chemical & Physical Properties

[ Boiling Point ]:
542.8ºC at 760mmHg

[ Molecular Formula ]:
C13H21N3O6S2

[ Molecular Weight ]:
379.45200

[ Flash Point ]:
282.1ºC

[ Exact Mass ]:
379.08700

[ PSA ]:
187.73000

[ LogP ]:
3.87720

[ Vapour Pressure ]:
7.62E-12mmHg at 25°C

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds