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MM 77 dihydrochloride

Names

[ CAS No. ]:
159187-70-9

[ Name ]:
MM 77 dihydrochloride

[Synonym ]:
2,5-Pyrrolidinedione, 1-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-, hydrochloride (1:2)
1-{4-[4-(2-Methoxyphenyl)piperazin-1-yl]butyl}pyrrolidine-2,5-dione dihydrochloride
1-{4-[4-(2-Methoxyphenyl)-1-piperazinyl]butyl}-2,5-pyrrolidinedione dihydrochloride

Biological Activity

[Description]:

MM 77 dihydrochloride is a potent postsynaptic antagonist of the 5-HT1A receptor. MM 77 dihydrochloride exhibits anxiolytic-like activity[1][2].

[Related Catalog]:

Research Areas >> Neurological Disease
Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor
Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

[Target]

5-HT1A Receptor


[References]

[1]. Briones-Aranda Alfredo, et al. Effect of the postsynaptic 5-HT1A receptor antagonist MM-77 on stressed mice treated with 5-HT1A receptor agents. Eur J Pharmacol. 2005 Jan 31;508(1-3):155-8.

[2]. Andrzej J Bojarski, et al. New imide 5-HT1A receptor ligands - modification of terminal fragment geometry. Molecules. 2004 Feb 28;9(3):170-7.

Chemical & Physical Properties

[ Molecular Formula ]:
C19H29Cl2N3O3

[ Molecular Weight ]:
418.358

[ Exact Mass ]:
417.158600

[ Storage condition ]:
-20°C

Related Compounds