Methyl 2-(7-hydroxy-2-oxo-2H-chromen-4-yl)acetate

Names

[ Name ]:
Methyl 2-(7-hydroxy-2-oxo-2H-chromen-4-yl)acetate

[Synonym ]:
methyl 2-(7-hydroxy-2-oxo-2H-chromen-4-yl)acetate
methyl (7-hydroxy-2-oxo-2H-chromen-4-yl)acetate
(7-Hydroxy-2-oxo-2H-chromen-4-yl)-acetic acid methyl ester
7-hydroxy-4-methoxycarbonylmethyl-2H-chromen-2-one
methyl 2-(7-hydroxy-2-oxochromen-4-yl) acetate
(7'-hydroxycoumarin-4-yl)acetic acid methyl ester
7-hydroxycoumarin-4-acetic acid methyl ester

Biological Activity

[Description]:

Methyl 2-(7-hydroxy-2-oxo-2H-chromen-4-yl)acetate, a natural coumarins derivative, is exploited for the synthesis of the switchable fluorescent substrates to be used in bacterial enzyme detection[1][2][3].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

Methyl 2-(7-hydroxy-2-oxo-2H-chromen-4-yl)acetate (compound 2) exhibits the maximum absorption (λabs~322 nm) and emission (λem~387 nm) wavelengths[2].

[References]

[1]. Nascimento JSD, et al. Mapping the Biotransformation of Coumarins through Filamentous Fungi. Molecules. 2019 Sep 29;24(19).

[2]. Lizzul-Jurse A, et al. Readily functionalizable phosphonium-tagged fluorescent coumarins for enhanced detection of conjugates by mass spectrometry. Org Biomol Chem. 2016 Aug 10;14(32):7777-91.

[3]. Giovannini G, et al. Coumarin-based, switchable fluorescent substrates for enzymatic bacterial detection. Talanta. 2018 Oct 1;188:448-453.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₂H₁₀O₅

[ Molecular Weight ]:
234.20500

[ Exact Mass ]:
234.05300

[ PSA ]:
76.74000

[ LogP ]:
1.21410

Safety Information

[ HS Code ]:
2932209090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2932209090

[ Summary ]:
2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%