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Sabcomeline hydrochloride

Names

[ CAS No. ]:
159912-58-0

[ Name ]:
Sabcomeline hydrochloride

Biological Activity

[Description]:

Sabcomeline (hydrochloride) is a potent and functionally selective muscarinic M1 receptor partial agonist that improve cognition.

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> mAChR

Signaling Pathways >> GPCR/G Protein >> mAChR

Research Areas >> Neurological Disease

[References]

[1]. Hosoi R, Kobayashi K, Ishida J, Yamaguchi M, Inoue O. Effect of sabcomeline on muscarinic and dopamine receptor binding in intact mouse brain. Ann Nucl Med. 2003;17(2):123-130.

[2]. Hatcher JP, Loudon JM, Hagan JJ, Clark MS. Sabcomeline (SB-202026), a functionally selective M1 receptor partial agonist, reverses delay-induced deficits in the T-maze. Psychopharmacology (Berl). 1998;138(3-4):275-282.

Chemical & Physical Properties

[ Boiling Point ]:
278.1ºC at 760 mmHg

[ Molecular Formula ]:
C₁₀H₁₆ClN₃O

[ Molecular Weight ]:
229.70700

[ Flash Point ]:
122ºC

[ Exact Mass ]:
229.09800

[ PSA ]:
48.62000

[ LogP ]:
1.59408

[ Vapour Pressure ]:
0.00436mmHg at 25°C

Related Compounds