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Deruxtecan analog

Names

[ CAS No. ]:
1599440-13-7

[ Name ]:
Deruxtecan analog

Biological Activity

[Description]:

Deruxtecan analog is a drug-linker conjugate for antibody-drug conjugate (ADC) extracted from patent WO2017002776A1, compound 1.

[Related Catalog]:

Signaling Pathways >> Antibody-drug Conjugate >> Drug-Linker Conjugates for ADC
Research Areas >> Cancer

[Target]

Drug-linker conjugates for ADC[1]


[In Vitro]

Antibody-drug conjugates deliver anticancer agents selectively and efficiently to tumor tissue and have significant antitumor efficacy with a wide therapeutic window[2].

[References]

[1]. NOGUCHI, Shigeru, et al. METHOD FOR SELECTIVELY MANUFACTURING ANTIBODY-DRUG CONJUGATE. WO2017002776A1.

[2]. Ogitani Y, et al. Bystander killing effect of DS-8201a, a novel anti-human epidermal growth factor receptor 2 antibody-drug conjugate, in tumors with human epidermal growth factor receptor 2 heterogeneity. Cancer Sci. 2016 Jul;107(7):1039-46.


[Related Small Molecules]

VcMMAE | Mertansine | dm1-smcc | McMMAF | Val-Cit-PAB-MMAE | Mc-MMAE | Acetylene-linker-Val-Cit-PABC-MMAE | SPDB-DM4 | Fmoc-Val-Cit-PAB-MMAE | Mc-MMAD | sulfo-SPDB-DM4

Chemical & Physical Properties

[ Density]:
1.48±0.1 g/cm3

[ Boiling Point ]:
1491.1±65.0 °C

[ Molecular Formula ]:
C52H56FN9O13

[ Molecular Weight ]:
1034.05

Related Compounds