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Dimethoxycurcumin

Names

[ CAS No. ]:
160096-59-3

[ Name ]:
Dimethoxycurcumin

[Synonym ]:
Di-O-methylchlordeoxydecarboxyphomazarin
4',4''-O,O-dimethylcurcumin
1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-, (1E,6E)-
(1E,6E)-1,7-Bis(3,4-dimethoxyphenyl)hepta-1,6-diene-3,5-dione
curcumin di-O-methyl ether
di-O-methylcurcumin
1,7-Bis-(3,4-dimethoxy-phenyl)-hepta-1,6-diene-3,5-dione
(1E,6E)-1,7-Bis(3,4-dimethoxyphenyl)-1,6-heptadiene-3,5-dione
Dimethylcurcumin
Dimethoxycurcumin(DiMC)

Biological Activity

[Description]:

Dimethoxycurcumin is a derivative of curcumin that has anti-inflammatory and antioxidant activities[1][2].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> NO Synthase
Research Areas >> Inflammation/Immunology

[References]

[1]. Patwardhan RS, et al. Dimethoxycurcumin, a metabolically stable analogue of curcumin, exhibits anti-inflammatory activities in murine and human lymphocytes. Biochem Pharmacol

[2]. Pae HO, et al. Dimethoxycurcumin, a synthetic curcumin analogue with higher metabolic stability, inhibits NO production, inducible NO synthase expression and NF-kappaB activation in RAW264.7 macrophages activated with LPS. Mol Nutr Food Res. 2008 Sep;52(9):1082-91.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
587.0±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C23H24O6

[ Molecular Weight ]:
396.43

[ Flash Point ]:
254.4±30.2 °C

[ Exact Mass ]:
396.157288

[ PSA ]:
71.06000

[ LogP ]:
4.11

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.585

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream