iocetamic acid (200 mg)

Names

[ Name ]:
iocetamic acid (200 mg)

[Synonym ]:
Cholimil
DRC 1201
Acide iocetamique [INN-French]
N-(3-amino-2,4,6-triiodophenyl)-3-acetamido-2-methyl-propionic acid
Colebrina
IOCETAMIC ACID
Acidum jocetamicum
Iocetamsaeure
Acidum iocetamicum [INN-Latin]
Cholebrine
Acido iocetamico [INN-Spanish]

Biological Activity

[Description]:

Cholebrine (DRC 1201), a diagnostic aid, is an orally active chotecystographic contrast agent[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vivo]

Cholebrine 在大鼠中 LD50 为 7 g/kg (口服) 和 0.7 g/kg (静脉注射)[2].

[References]

[1]. Owen JP, et al. Comparative study of iocetamic acid and calcium ipodate in the visualisation of the gallbladder and common bile duct. Clin Radiol. 1978 Sep;29(5):535-40.

[2]. Janbroers JM, et al. Toxicologic studies of iocetamic acid in rats and dogs. Toxicol Appl Pharmacol. 1969 Mar;14(2):242-8.

Chemical & Physical Properties

[ Density]:
2.416g/cm3

[ Boiling Point ]:
658.2ºC at 760 mmHg

[ Melting Point ]:
224-225ºC

[ Molecular Formula ]:
C₁₂H₁₃I₃N₂O₃

[ Molecular Weight ]:
613.95700

[ Flash Point ]:
351.9ºC

[ Exact Mass ]:
613.80600

[ PSA ]:
83.63000

[ LogP ]:
3.73740

[ Vapour Pressure ]:
3.21E-18mmHg at 25°C

[ Index of Refraction ]:
1.75

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UE6050000

CHEMICAL NAME :: Propionic acid, 3-(acetyl-(3-amino-2,4,6-triiodophenyl)amino)-2-methy l-

CAS REGISTRY NUMBER :: 16034-77-8

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C12-H13-I3-N2-O3

MOLECULAR WEIGHT :: 613.97

WISWESSER LINE NOTATION :: ZR BI DI FI CNV1&1Y1&VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 7100 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - acute pulmonary edema Gastrointestinal - other changes

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 14,232,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 700 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - acute pulmonary edema Gastrointestinal - other changes

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 14,232,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 410 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 13,997,1970 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6131 No. of Facilities: 10 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 260 (estimated) No. of Female Employees: 140 (estimated)

Safety Information

[ HS Code ]:
2924299090

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%