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TX1-85-1

Names

[ CAS No. ]:
1603845-32-4

[ Name ]:
TX1-85-1

Biological Activity

[Description]:

TX1-85-1 is a Her3 (ErbB3) inhibitor with an IC50 of 23 nM. TX1-85-1 induces partial degradation of Her3 protein and attenuates Her3-dependent signaling[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> JAK/STAT Signaling >> EGFR
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR

[Target]

ErbB3:23 nM (IC50)


[References]

[1]. Xie T, et al. Pharmacological targeting of the pseudokinase Her3. Nat Chem Biol. 2014 Dec;10(12):1006-12.

Chemical & Physical Properties

[ Molecular Formula ]:
C32H36N8O3

[ Molecular Weight ]:
580.679999999999

[ Storage condition ]:
2-8℃

Related Compounds