TX2-121-1

Names

[ Name ]:
TX2-121-1

Biological Activity

[Description]:

TX2-121-1 is a bivalent hydrophobically tagged adamantane derivative of TX1-85-1, a potent, selective, ATP-competitive Her3 (ErbB3) inhibitor; induces degradation and interferences with Her2/Her3 and c-Met/Her3 interactions, prevents Her3 heterodimerization, induces preferential death of Her3-dependent cell lines with an EC50 in the range of 0.8-1.4 uM.

[References]

References 1. Xie T, et al. Nat Chem Biol. 2014 Dec;10(12):1006-12. View Related Products by Target EGFR

Chemical & Physical Properties

[ Molecular Formula ]:
C₄₂H₅₂N₈O₃

[ Molecular Weight ]:
716.931

Related Compounds

BCI-121
N,N-bis(chloromethyl)acetamide
1,1,2,2-tetrachloro-1-fluoroethane
Diallyl bisphenol A
1-[1-(3,4-dimethoxyphenyl)propyl]piperidine,hydrochloride
Fatty acids, tall-oil, Me esters, reaction products with sulfurized lard oil
1-(3-Chlorobenzyl)-3'-(4-ethoxyphenyl)spiro[indoline-3,2'-thiazolidine]-2,4'-dione 1',1'-dioxide
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
tert-Butyl-DL-alanine
4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide