SCH 50911 hydrochloride

Names

[ Name ]:
SCH 50911 hydrochloride

[Synonym ]:
(+)-(2S)-5,5-Dimethyl-2-morpholineacetic acid hydrochloride

Biological Activity

[Description]:

SCH 50911 hydrochloride, (+)-(S)-5,5-dimethylmorpholinyl-2-acetic acid, a selective, orally-active and competitive γ-Aminobutyric acid B GABA(B) receptor antagonist, binds to GABA(B) receptor with IC50 of 1.1 μM. SCH 50911 hydrochloride antagonizes GABA(B) autoreceptors, increasing the electrically-stimulated 3H overflow with an IC50 of 3 μM.

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> GABA Receptor

[Target]

GABA(B):1.1 μM (IC50)

[References]

[1]. Ong J, et al. The morpholino-acetic acid analogue Sch 50911 is a selective GABA(B) receptor antagonist in rat neocortical slices. Eur J Pharmacol. 1998 Nov 27;362(1):35-41.

Chemical & Physical Properties

[ Density]:
1.055 g/cm3

[ Boiling Point ]:
305.5ºC at 760 mmHg

[ Molecular Formula ]:
C₈H₁₆ClNO₃

[ Molecular Weight ]:
173.21000

[ Flash Point ]:
138.6ºC

[ Exact Mass ]:
173.10500

[ PSA ]:
58.56000

[ LogP ]:
0.55690

[ Vapour Pressure ]:
0.000187mmHg at 25°C

[ Index of Refraction ]:
1.444

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H317

[ Precautionary Statements ]:
P280

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2934999090

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%