Osanetant

Names

[ Name ]:
Osanetant

Biological Activity

[Description]:

Osanetant (SR142801) is a selective NK3 receptor antagonist. Osanetant produces anxiolytic- and antidepressant-like effects and is researched for the treatment of schizophrenia[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor

[Target]

NK3

[In Vivo]

Osanetant (SR142801; po; 1-10 mg/kg; 60 min before testing) significantly increases social interaction time[1]. Osanetant (ip; 5 and 10 mg/kg; 30 min before testing) decreases immobility time[1]. Animal Model: Male Mongolian gerbils of 7 weeks old (50-60 g)[1] Dosage: 1, 3 and 10 mg/kg Administration: Po; 60 min before testing Result: Significantly increased social interaction time.

[References]

[1]. Salomé N, et al. Selective blockade of NK2 or NK3 receptors produces anxiolytic- and antidepressant-like effects in gerbils. Pharmacol Biochem Behav. 2006 Apr;83(4):533-9.

Chemical & Physical Properties

[ Density]:
1.25g/cm3

[ Boiling Point ]:
727.9ºC at 760mmHg

[ Molecular Formula ]:
C₃₅H₄₁Cl₂N₃O₂

[ Molecular Weight ]:
606.62500

[ Flash Point ]:
394ºC

[ Exact Mass ]:
605.25800

[ PSA ]:
43.86000

[ LogP ]:
7.29300

[ Vapour Pressure ]:
4.79E-21mmHg at 25°C

[ Index of Refraction ]:
1.633

[ Storage condition ]:
-20°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport