HEPPS

Names

[ Name ]:
HEPPS

[Synonym ]:
HEPPS
3-[4-(2-Hydroxyethyl)-1-piperazinyl]propanesulfonic Acid
EINECS 240-198-8
MFCD00006160
3-[4-(2-Hydroxyethyl)-1-piperazinyl]-1-propanesulfonic acid
3-(4-(2-Hydroxyethyl)piperazin-1-yl)propane-1-sulfonic acid
4-(2-Hydroxyethyl)-1-piperazinepropanesulfonic Acid [Good's buffer component
1-Piperazinepropanesulfonic acid, 4-(2-hydroxyethyl)-
3-[4-(2-Hydroxyethyl)piperazin-1-yl]propane-1-sulfonic acid
EPPS
4-Hydroxyerhylpiperazine-1-propanesulfonic acid

Biological Activity

[Description]:

HEPPS (EPPS) is a buffering agent with the useful pH range from 7.3 ~ 8.7. HEPPS reduces Aβ-aggregate-induced memory deficits and rescues cognitive deficits in mice. EPPS is orally active and penetrates the blood-brain barrier[1].

[Related Catalog]:

Research Areas >> Neurological Disease

[References]

[1]. Kim HY, et al. EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaques. Nat Commun. 2015 Dec 8;6:8997.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Melting Point ]:
237-239 °C(lit.)

[ Molecular Formula ]:
C₉H₂₀N₂O₄S

[ Molecular Weight ]:
252.331

[ Exact Mass ]:
252.114380

[ PSA ]:
89.46000

[ LogP ]:
-2.46

[ Index of Refraction ]:
1.537

[ Storage condition ]:
Store at RT.

[ Water Solubility ]:
H2O: 1 M at 20 °C, clear, colorless

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TM2649130

CHEMICAL NAME :: 1-Piperazinepropanesulfonic acid, 4-(2-hydroxyethyl)-

CAS REGISTRY NUMBER :: 16052-06-5

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C9-H20-N2-O4-S

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: >316 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1977- Volume(issue)/page/year: 6,149,1982

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
TM2649130

[ HS Code ]:
29335995

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Comparison of MDCK-MDR1 and Caco-2 cell based permeability assays for anti-malarial drug screening and drug investigations.

J. Pharmacol. Toxicol. Methods 70(2) , 188-94, (2014)

Malaria is a major health concern and affects over 300million people a year. Accordingly, there is an urgent need for new efficacious anti-malarial drugs. A major challenge in developing new anti-mala...

Heat Shock Protein 90 Associates with the Per-Arnt-Sim Domain of Heme-free Soluble Guanylate Cyclase: IMplications for Enzyme Maturation.

J. Biol. Chem. 290 , 21615-28, (2015)

Heat shock protein 90 (hsp90) drives heme insertion into the β1 subunit of soluble guanylate cyclase (sGC) β1, which enables it to associate with a partner sGCα1 subunit and mature into a nitric oxide...

EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaques.

Nat. Commun. 6 , 8997, (2015)

Alzheimer's disease (AD) is characterized by the transition of amyloid-β (Aβ) monomers into toxic oligomers and plaques. Given that Aβ abnormality typically precedes the development of clinical sympto...