QBS

Names

[ Name ]:
QBS

[Synonym ]:
AmbscL35/057
2-AMINO-N-QUINOLINE-8-YLBENZENESULFONAMIDE
N-(quinolin-8-yl)-2-amino-benzenesulfonamide
8-(2-Aminophenylsulfonylamino)chinolin
QBS
2-Amino-N-quinolin-8-yl-benzenesulfonamide

Biological Activity

[Description]:

NUN82647 inhibits cell cycle at G2 phase and induces apoptosis[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

[References]

[1]. Kim YH, et al. G2 arrest and apoptosis by 2-amino-N-quinoline-8-yl-benzenesulfonamide (QBS), a novel cytotoxic compound. Biochem Pharmacol. 2005 May 1;69(9):1333-41.

Chemical & Physical Properties

[ Density]:
1.437g/cm3

[ Boiling Point ]:
540.7ºC at 760 mmHg

[ Molecular Formula ]:
C₁₅H₁₃N₃O₂S

[ Molecular Weight ]:
299.35

[ Flash Point ]:
280.8ºC

[ Exact Mass ]:
299.07300

[ PSA ]:
93.46000

[ LogP ]:
4.35280

[ Vapour Pressure ]:
9.36E-12mmHg at 25°C

[ Index of Refraction ]:
1.727

[ Storage condition ]:
2-8°C

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2935009090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2935009090

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

Articles

G2 arrest and apoptosis by 2-amino-N-quinoline-8-yl-benzenesulfonamide (QBS), a novel cytotoxic compound.

Biochem. Pharmacol. 69 , 1333-1341, (2005)

We screened a library of 11,000 small molecular weight chemicals, looking for compounds that affect cell viability. We have identified 2-amino-N-quinoline-8-yl-benzenesulfonamide (QBS) as a potent cyt...

ADAM-mediated amphiregulin shedding and EGFR transactivation.

Cell Prolif. 42 , 799-812, (2009)

The ectodomain shedding of epidermal growth factor receptor (EGFR) ligands, such as amphiregulin (AREG), by ADAMs (A Disintegrin And Metalloproteases) can be stimulated by G protein-coupled receptor (...