Tyk2-IN-7
Names
[ CAS No. ]:
1609391-90-3
[ Name ]:
Tyk2-IN-7
Biological Activity
[Description]:
Tyk2-IN-7 (Compound 48) is a TYK2 JH2 inhibitor, binds to TYK2 JH2 domain with IC50 and Ki.app of 0.00053 μM and 0.00007 μM, respectively. Tyk2-IN-7 (Compound 48) provides a highly selective alternative to conventional TYK2 orthosteric inhibitors, inhibits TYK2/JAK1/JAK2 kinase domain. Tyk2-IN-7 (Compound 48) provides robust inhibition in a mouse IL-12-induced IFNγ pharmacodynamic model as well as efficacy in an IL-23 and IL-12-dependent mouse colitis model[1].
[Related Catalog]:
[Target]
Tyk2 JH2:0.00053 μM (IC50)
Tyk2 JH2:0.00007 μM (Ki app)
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C18H15D3N6O3S
[ Molecular Weight ]:
401.46