<Suppliers Price>

Alkyne-PEG4-maleimide

Names

[ CAS No. ]:
1609651-90-2

[ Name ]:
Alkyne-PEG4-maleimide

[Synonym ]:
3-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-(3,6,9,12-tetraoxapentadec-14-yn-1-yl)propanamide
1H-Pyrrole-1-propanamide, 2,5-dihydro-2,5-dioxo-N-3,6,9,12-tetraoxapentadec-14-yn-1-yl-
Propargyl-PEG4-Maleimide

Biological Activity

[Description]:

Alkyne-PEG4-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
575.8±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C18H26N2O7

[ Molecular Weight ]:
382.408

[ Flash Point ]:
302.1±30.1 °C

[ Exact Mass ]:
382.174011

[ LogP ]:
-1.51

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.513

Related Compounds