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Mitochonic Acid 35

Names

[ CAS No. ]:
1611470-23-5

[ Name ]:
Mitochonic Acid 35

[Synonym ]:
{5-[(3,5-Dimethoxybenzyl)oxy]-1H-indol-3-yl}acetic acid
1H-Indole-3-acetic acid, 5-[(3,5-dimethoxyphenyl)methoxy]-

Biological Activity

[Description]:

A dual inhibitor of TNF-α and TGF-β1 by inhibiting IκB kinase phosphorylation and Smad3 phosphorylation; attenuates the LPS/GaIN-induced hepatic inflammation in the mice, and downregulates TGF-β1-induced fibrotic gene expression; attenuates renal inflammation and fibrosis with the downregulation of inflammatory cytokines and fibrotic gene expressions in renal fibrosis model.

[References]

References 1. Shima H, et al. Sci Rep. 2017 May 15;7(1):1884. View Related Products by Target TNF-alpha

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
595.2±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C19H19NO5

[ Molecular Weight ]:
341.358

[ Flash Point ]:
313.7±28.7 °C

[ Exact Mass ]:
341.126312

[ LogP ]:
2.71

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.638

Related Compounds