1,2-Di-O-acetyl-3-deoxy-3-fluoro-5-O-(4-methyl)benzoyl-D-ribofuranose

Names

[ CAS No. ]:
1612192-28-5

[ Name ]:
1,2-Di-O-acetyl-3-deoxy-3-fluoro-5-O-(4-methyl)benzoyl-D-ribofuranose

[Synonym ]:
1,2-Di-O-acetyl-3-deoxy-3-fluoro-5-O-(4-methylbenzoyl)-β-D-glycero-pentofuranose
β-D-glycero-Pentofuranose, 3-deoxy-3-fluoro-, 1,2-diacetate 5-(4-methylbenzoate)

Biological Activity

[Description]:

1,2-Di-O-acetyl-3-deoxy-3-fluoro-5-O-(4-methyl)benzoyl-D-ribofuranose is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
440.0±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C17H19FO7

[ Molecular Weight ]:
354.33

[ Flash Point ]:
212.1±23.6 °C

[ Exact Mass ]:
354.111481

[ LogP ]:
3.13

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.517

Related Compounds