KBP-7018 hydrochloride

Names

[ Name ]:
KBP-7018 hydrochloride

Biological Activity

[Description]:

A novel potent, multikinase inhibitor with IC50 of 10, 7.6 and 25 nM for c-Kit, RET and PDGFRβ, respectively; also potently inhibits FLT3, VEGFR2, Fyn, PDGFRα and VEGFR2; shows promising outcomes for the treatments of idiopathic pulmonary fibrosis (IPF).

[References]

References 1. Huang Z, et al. ACS Med Chem Lett. 2017 Sep 30;8(11):1142-1147. 2. Huang Z, et al. Drug Des Devel Ther. 2015 Aug 5;9:4319-28. View Related Products by Target c-Kit

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₁H₃₁ClN₄O₅

[ Molecular Weight ]:
575.06

Related Compounds

KBP-7018
(S)-Amphetamine-D6 Hydrochloride
Desmethylcyclobenzaprine-d3 hydrochloride
Midodrine D6 hydrochloride
N-Methylalaninamide hydrochloride (1:1)
3-Methyl-5-[(2S)-1-methyl-2-pyrrolidinyl]isoxazole hydrochloride
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
3-(2-Methylpyridin-3-yl)prop-2-enoic acid hydrochloride
3-(Furan-2-yl)-2-azaspiro[3.4]octan-1-one
6-(2-Methyl-1H-imidazol-4-YL)pyridine-3-carboxylic acid
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-(4-{[(Tert-butoxy)carbonyl]amino}-2-fluorophenyl)acetic acid
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide