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DprE1-IN-2

Names

[ CAS No. ]:
1615713-87-5

[ Name ]:
DprE1-IN-2

[Synonym ]:
1-{[6-(Dimethylamino)-5-methyl-4-pyrimidinyl]methyl}-N-(2-hydroxyethyl)-6-methyl-1H-pyrrolo[3,2-b]pyridine-3-carboxamide
1H-Pyrrolo[3,2-b]pyridine-3-carboxamide, 1-[[6-(dimethylamino)-5-methyl-4-pyrimidinyl]methyl]-N-(2-hydroxyethyl)-6-methyl-
DprE1-IN-2

Biological Activity

[Description]:

DprE1-IN-2 is a potent DprE1 inhibitor.target: DprE1In vitro: DprE1-IN-2 demonstrats efficacy in a rodent model of tuberculosis, making it promising for further development.

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Cancer

[References]

[1]. Shirude PS et al. Lead optimization of 1,4-azaindoles as antimycobacterial agents. J Med Chem. 2014 Jul 10;57(13):5728-37.


[Related Small Molecules]

Captisol | Cyclosporin A | H2DCFDA | 0MPTP hydrochloride | GW4869 | Etomoxir | TD139 | Mitoquinone mesylate | GSK2795039 | JC-1 | BAPTA-AM | AP 20187 | Setanaxib (GKT137831) | D-Luciferin | Crotaline

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
701.4±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C19H24N6O2

[ Molecular Weight ]:
368.433

[ Flash Point ]:
378.0±32.9 °C

[ Exact Mass ]:
368.196075

[ LogP ]:
1.46

[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C

[ Index of Refraction ]:
1.649

[ Storage condition ]:
2-8℃

Related Compounds