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MC-Val-Cit-PAB-NH-C2-NH-Boc

Names

[ CAS No. ]:
1616727-22-0

[ Name ]:
MC-Val-Cit-PAB-NH-C2-NH-Boc

Biological Activity

[Description]:

MC-Val-Cit-PAB-NH-C2-NH-Boc is a cathepsin cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[Target]

Cleavable

[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

[References]

[1]. Akaiwa M, et al. Synthesis and Evaluation of Linear and Macrocyclic Dolastatin 10 Analogues Containing Pyrrolidine Ring Modifications. ACS Omega. 2018;3(5):5212-5221.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₆H₅₄N₈O₁₀

[ Molecular Weight ]:
758.86

Related Compounds