Adenosine-5'-diphosphate disodium salt

Names

[ Name ]:
Adenosine-5'-diphosphate disodium salt

[Synonym ]:
Adenosine 5'-Diphosphate Disodium Salt Hydrate
EINECS 240-314-7
adenosine diphosphate sodium salt
Adenosine 5′-diphosphate disodium salt
5'-ADP-Na2
Adenosine 5'-diphosphate disodium salt
5'-ADP Na Hydrate
Adenosine, 5'-(trihydrogen diphosphate), sodium salt (1:2)
Disodium 5'-O-{[(hydroxyphosphinato)oxy]phosphinato}adenosine
Adenosine 5‘-diphosphate,disodium salt hydrate
MFCD00066635
Adenosine-5'-diphosphatedisodiumsalt

Biological Activity

[Description]:

Adenosine 5'-diphosphate disodium is a nucleoside diphosphate. Adenosine 5'-diphosphate disodium is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate disodium is a platelet aggregation agent for hemostasis and the development and extension of arterial thrombosis[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

[Target]

Human Endogenous Metabolite

[In Vitro]

Adenosine 5'-diphosphate disodium (10 μmol/L) 诱导人血小板聚集以及血小板，B10 细胞和 p2y1 转染细胞中的 [Ca2+]i 的增加[1]。 Adenosine 5'-diphosphate disodium (5 μmol/L) 可提高人血小板和 B10 细胞中 cAMP 的水平[1]。

[References]

[1]. Hechler B, et al. The P2Y1 receptor is necessary for adenosine 5'-diphosphate-induced platelet aggregation. Blood. 1998 Jul 1;92(1):152-9.

[2]. Arts IC, et al. Adenosine 5'-triphosphate (ATP) supplements are not orally bioavailable: a randomized, placebo-controlled cross-over trial in healthy humans. J Int Soc Sports Nutr. 2012 Apr 17;9(1):16.

Chemical & Physical Properties

[ Boiling Point ]:
877.7ºC at 760 mmHg

[ Molecular Formula ]:
C₁₀H₁₃N₅Na₂O₁₀P₂

[ Molecular Weight ]:
471.165

[ Flash Point ]:
484.6ºC

[ Exact Mass ]:
470.993317

[ PSA ]:
257.88000

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

A novel surface-confined glucaminium-based ionic liquid stationary phase for hydrophilic interaction/anion-exchange mixed-mode chromatography.

J. Chromatogr. A. 1360 , 240-7, (2014)

Glucaminium-based ionic liquids are a new class of recently developed ionic liquids and prepared by functionalizing the amine group of N-methyl-d-glucamine, which renders them good hydrophilicity due ...

Adenosine derived from ADP can contribute to inhibition of platelet aggregation in the presence of a P2Y12 antagonist.

Arterioscler. Thromb. Vasc. Biol. 31 , 416-422, (2011)

To investigate whether adenosine diphosphate (ADP)-derived adenosine might inhibit platelet aggregation, especially in the presence of a P2Y₁₂ antagonist, where the effects of ADP at the P2Y₁₂ recepto...

Extracellular Ca(2+) modulates ADP-evoked aggregation through altered agonist degradation: implications for conditions used to study P2Y receptor activation.

Br. J. Haematol. 153 , 83-91, (2011)

ADP is considered a weak platelet agonist due to the limited aggregation responses it induces in vitro at physiological concentrations of extracellular Ca(2+) [(Ca(2+) )(o) ]. Lowering [Ca(2+) ](o) pa...