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DABCYL-Tyr-Val-Ala-Asp-Ala-Pro-Val-EDANS trifluoroacetate salt

Names

[ CAS No. ]:
161877-70-9

[ Name ]:
DABCYL-Tyr-Val-Ala-Asp-Ala-Pro-Val-EDANS trifluoroacetate salt

[Synonym ]:
DABCYL-TYR-VAL-ALA-ASP-ALA-PRO-VAL-EDANS
INTERLEUKIN-1BETA CONVERTING ENZYME SUBSTRATE II
ICE SUBSTRATE II
PASE 1 (ICE) SUBSTRATE
4-(4'-dimethylaminophenylazo)benzoyl-tyrosyl-valyl-alanyl-aspartyl-alanyl-prolyl-valyl-5((2-aminoethyl)amino)naphthalene-1-sulfonic acid
DABCYL-YVADAPV-EDANS
4-(4-DIMETHYLAMINOPHENYLAZO)BENZOYL-TYR-VAL-ALA-ASP-ALA-PRO-VAL-5-[(2-AMINOETHYL)AMINO]-NAPHTHALENE-1-SULFONIC ACID
Caspase 1 (ICE) substrate for FRET assays
IL-1B CONVERTING ENZYME SUBSTRATE II

Biological Activity

[Description]:

Dabcyl-YVADAPV-EDANS is a fluorogenic interleukin-1β converting enzyme (ICE) substrate for measuring ICE-like protease activity. Dabcyl-YVADAPV-EDANS detects fluorescence at 360 nm excitation and 480 nm emission wavelengths. ICE-like protease is a critical mediator of K+ deprivation-induced apoptosis of cerebellar granule neurons[1].

[Related Catalog]:

Research Areas >> Others

[References]

[1]. Schulz JB, et al. Potassium deprivation-induced apoptosis of cerebellar granule neurons: a sequential requirement for new mRNA and protein synthesis, ICE-like protease activity, and reactive oxygen species. J Neurosci. 1996 Aug 1;16(15):4696-706.  

Chemical & Physical Properties

[ Density]:
1.38g/cm3

[ Molecular Formula ]:
C61H76N12O14S

[ Molecular Weight ]:
1233.39

[ Exact Mass ]:
1232.53000

[ PSA ]:
384.28000

[ LogP ]:
7.91240

[ Index of Refraction ]:
1.654

Related Compounds