Acivicin hydrochloride
Names
[ CAS No. ]:
161922-40-3
[ Name ]:
Acivicin hydrochloride
Biological Activity
[Description]:
Acivicin hydrochloride (AT-125 hydrochloride), a natural product produced by Streptomyces sviceus, is a γ−glutamyl transpeptidase (GGT) inhibitor. Acivicin hydrochloride can across the blood-brain barrier and has anti-cancer, anti-parasitic properties[1][2].
[Related Catalog]:
[Target]
γ−glutamyl transpeptidase[1]
[In Vitro]
Acivicin hydrochloride (AT-125 hydrochloride; 0.1-50 μM; 5 days) has an IC50 of 0.7 μM in human HepG2 cells[1].
[In Vivo]
Acivicin hydrochloride (AT-125 hydrochloride; 0.1-50 μM; 5 days; for 4 days) reduces urinary gamma-GT by 70-78%[1]. Animal Model: Male pigmented Long-Evans rats weighed between 250 g and 300 g exposed to Toluene[1] Dosage: 5 mg/kg Administration: IP; twice weekly (monday and wednesday); for 4 days Result: Reduced urinary gamma-GT by 70-78%.
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C5H8Cl2N2O3
[ Molecular Weight ]:
215.03