6-Chloro-2-hydroxy-9-(2',3',5'-tri-O-acetyl-b-D-ribofuranosyl)purine

Names

[ CAS No. ]:
161923-50-8

[ Name ]:
6-Chloro-2-hydroxy-9-(2',3',5'-tri-O-acetyl-b-D-ribofuranosyl)purine

[Synonym ]:
6-chloropyrazine-2-ylhydrazine
2-chloro-6-hydrazinopyridazine
2-Hydrazino-6-chlorpyrazin
2-Chloro-6-hydrazinylpyrazine
2',3',5'-triacetyl-6-chloroguanosine
6-chloro-2-hydrazinopyrazine
2-chloro-6-hydrazino-pyrazine

Biological Activity

[Description]:

6-Chloro-2-hydroxy-9-(2',3',5'-tri-O-acetyl-β-D-ribofuranosyl)purine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₁₇ClN₄O₈

[ Molecular Weight ]:
428.78

[ Exact Mass ]:
428.07300

[ PSA ]:
151.96000

[ LogP ]:
0.50920

[ Index of Refraction ]:
1.678

6-Chloro-2-hydroxy-9-(2',3',5'-tri-O-acetyl-b-D-ribofuranosyl)purine

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream