RSK2-IN-3

Names

[ CAS No. ]:
1627136-54-2

[ Name ]:
RSK2-IN-3

Biological Activity

[Description]:

RSK2-IN-3 (Compound 26) is a reversible covalent inhibitor of the RPS6KA3 (RSK2) kinase[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> MAPK/ERK Pathway >> Ribosomal S6 Kinase (RSK)

[Target]

RSK2:8.3 (pIC50, ERK2-MSK1 cascade)

RSK2:9.2 (pIC50, MSK1 CTKD)

[References]

[1]. Hall A, et al. Discovery and Characterization of a Novel Series of Chloropyrimidines as Covalent Inhibitors of the Kinase MSK1. ACS Med Chem Lett. 2022 Jun 25;13(7):1099-1108.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₂₆N₄O₅

[ Molecular Weight ]:
450.49

Related Compounds