VS-II-173

VS-II-173 is a highly potent Pim1 and Pim3 inhibitor with IC50 of 70 and 20 nM respectively, and a potent and selective inducer of AML cell death (IC50=5.5 uM, Molm-13 cell); acts synergistically with the anthracycline daunorubicin, and additively with a number of other anti-cancer drugs; attenuates phosphorylation of Pim kinase substrates, shows towards cell lines harboring the FLT3-ITD mutation (Molm-13, FLT3-ITD heterozygous and MV4-11 FLT3-ITD homozygous) with EC50 of 2-3 uM; also induces cell death also in AML patient blasts, including blast carrying high-risk FLT3-ITD mutation.

References 1. Suchaud V, et al. Bioorg Med Chem. 2014 Sep 1;22(17):4704-10. 2. Bjørnstad R, et al. Mol Cancer Ther. 2019 Jan 24. pii: molcanther.1234.2017. doi: 10.1158/1535-7163.MCT-17-1234. View Related Products by Target Pim