(S)-3,5-DHPG

Names

[ Name ]:
(S)-3,5-DHPG

[Synonym ]:
Benzeneacetic acid, α-amino-3,5-dihydroxy-, (αS)-
(2S)-Amino(3,5-dihydroxyphenyl)acetic acid
Amino(3,5-dihydroxyphenyl)acetic acid
Benzeneacetic acid, α-amino-3,5-dihydroxy-
(2S)-amino(3,5-dihydroxyphenyl)ethanoic acid
UNII:5YR2N37E6D
(S)-3,5-DHPG,(S)-3,5-Dihydroxyphenylglycine

Biological Activity

[Description]:

(S)-3,5-DHPG is a weak, but selective group I metabotropic glutamate receptors (mGluRs) agonist with Ki values of 0.9 µM and 3.9 µM for mGluR1a and mGluR5a, respectively[1]. (S)-3,5-DHPG exhibits anxiolytic activity in rats subjected to hypoxia[2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> mGluR

Research Areas >> Neurological Disease

[Target]

mGluR1a:0.9 μM (Ki)

mGluR5a:3.9 μM (Ki)

[In Vitro]

(S)-3,5-DHPG specifically displaces high-affinity quisqualate sites, the putative group I mGlu binding sites[1].

[In Vivo]

(S)-3,5-DHPG (icv; 0.01, 0.1 and 1.0 nmol/5 μL) improves consolidation and retrieval and exhibits anxiolytic activity in dose-dependent manner in male Wistar rats weighing 160-180 g subjected to hypoxia[2].

[References]

[1]. V Mutel, et al. Characterization of [(3)H]Quisqualate Binding to Recombinant Rat Metabotropic Glutamate 1a and 5a Receptors and to Rat and Human Brain Sections. J Neurochem. 2000 Dec;75(6):2590-601.

[2]. Agnieszka Nadlewska, et al. Effect of (S)-3,5-DHPG on Learning, Exploratory Activity and Anxiety in Rats With Experimental Hypoxia. Pol J Pharmacol. Jan-Feb 2002;54(1):11-8.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
448.8±33.0 °C at 760 mmHg

[ Molecular Formula ]:
C₈H₉NO₄

[ Molecular Weight ]:
183.161

[ Flash Point ]:
225.2±25.4 °C

[ Exact Mass ]:
183.053162

[ PSA ]:
103.78000

[ LogP ]:
-0.52

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.680

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26

[ HS Code ]:
2922509090

Customs

[ HS Code ]: 2922509090

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%