PD 0332991-d8

Names

[ Name ]:
PD 0332991-d8

Biological Activity

[Description]:

Palbociclib D8 (PD 0332991 D8) is a deuterium labeled Palbociclib. Palbociclib is a selective and orally active CDK4 and CDK6 inhibitor with IC50s of 11 and 16 nM, respectively. Palbociclib has no activity against other protein kinases. Palbociclib has potently anticancer activities[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> CDK

[Target]

Cdk4/cyclin D3:9 nM (IC50)

Cdk4/cyclin D1:11 nM (IC50)

Cdk6/cyclin D2:16 nM (IC50)

DYRK1A:2000 nM (IC50)

MAPK:8000 nM (IC50)

[References]

[1]. Fry DW, et al. Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts. Mol Cancer Ther. 2004 Nov;3(11):1427-38.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₂₁D₈N₇O₂

[ Molecular Weight ]:
455.58

[ Storage condition ]:
-20°C

PD 0332991-d8

Names

Biological Activity

Chemical & Physical Properties

Related Compounds