FGFR4-IN-2
Names
[ CAS No. ]:
1628793-01-0
[ Name ]:
FGFR4-IN-2
Biological Activity
[Description]:
FGFR4-IN-2 is a potent, selective, covalent FGFR4 inhibitor with cellualr IC50 of 8.8 nM, 100-fold selectivity over FGFR2.FGFR4-IN-2 potently and selectively inhibit FGFR4 signaling through covalent modification of Cys552.FGFR4-IN-2 induces tumor regression in preclinical models of orthotopic and sorafenib-resistant HCC.
[References]
1. Haibo Liu, et al. ACS Med Chem Lett. 2020 Mar 6;11(10):1899-1904.
Chemical & Physical Properties
[ Molecular Formula ]:
C23H23Cl2N5O5
[ Molecular Weight ]:
520.367