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BYK 49187

Names

[ CAS No. ]:
163120-31-8

[ Name ]:
BYK 49187

Biological Activity

[Description]:

AR-C66096 (FPL 66096) tetrasodium is a selective platelet P2YT receptor antagonist. AR-C66096 tetrasodium effectively blocks ADP-induced platelet aggregation. AR-C66096 tetrasodium can be used in the research of thromboembolism[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Epigenetics >> PARP
Signaling Pathways >> Cell Cycle/DNA Damage >> PARP

[Target]

pIC50: 8.36 (hPARP-1); 7.50 (mPARP-2)[1].


[References]

[1]. Eltze T, et al. Imidazoquinolinone, imidazopyridine, and isoquinolindione derivatives as novel and potent inhibitors of the poly(ADP-ribose) polymerase (PARP): a comparison with standard PARP inhibitors. Mol Pharmacol. 2008 Dec;74(6):1587-98.  

Chemical & Physical Properties

[ Molecular Formula ]:
C19H21N5O

[ Molecular Weight ]:
335.40

[ Exact Mass ]:
335.17500

[ PSA ]:
66.81000

[ LogP ]:
3.10320

Related Compounds