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MOG (35-55), human

Names

[ CAS No. ]:
163158-19-8

[ Name ]:
MOG (35-55), human

[Synonym ]:
h2n-mevgwyrppfsrvvhlyrngk-oh
myelin oligodendrocyte glycoprotein precursor

Biological Activity

[Description]:

MOG (35-55), human is a component of CNS myelin. MOG (35-55), human is different from mMOG (35-55) by a proline for serine substitution at position 42. MOG (35-55), human is also immunogenic, but not encephalitogenic, and is only partially cross-reactive with mMOG35–55. MOG (35-55), human induces minimal clinical signs of EAE relative to the rodent peptide[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Neurological Disease

[References]

[1]. Cathleen Rich, et al. Myelin oligodendrocyte glycoprotein-35-55 peptide induces severe chronic experimental autoimmune encephalomyelitis in HLA-DR2-transgenic mice. Eur J Immunol. 2004 May;34(5):1251-61.

[2]. Alfred R Oliver, et al.Rat and human myelin oligodendrocyte glycoproteins induce experimental autoimmune encephalomyelitis by different mechanisms in C57BL/6 mice. J Immunol. 2003 Jul 1;171(1):462-8.

Chemical & Physical Properties

[ Molecular Formula ]:
C120H179N35O28S

[ Molecular Weight ]:
2591.99000

[ Exact Mass ]:
2590.34000

[ PSA ]:
1050.31000

[ LogP ]:
6.20280

Related Compounds