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(-)-Chromanol 293B

Names

[ CAS No. ]:
163163-24-4

[ Name ]:
(-)-Chromanol 293B

[Synonym ]:
Chromanol 293B
HMS3267H14
HMR1556

Biological Activity

[Description]:

(-)-Chromanol 293B is a potent and selective inhibitor of the slow component of delayed rectifier K+ current (IKs). (-)-Chromanol 293B can be used for the research of antiarrhythmic[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> Others >> Others

[Target]

IKs[1]


[In Vitro]

(-)-Chromanol 293B selectively inhibits the KvLQT11＋minK ion channel complex[1].

[References]

[1]. Yang IC, et al. Stereoselective interactions of the enantiomers of chromanol 293B with human voltage-gated potassium channels. J Pharmacol Exp Ther. 2000;294(3):955-962.

Chemical & Physical Properties

[ Density]:
1.33g/cm3

[ Boiling Point ]:
474.1ºC at 760mmHg

[ Molecular Formula ]:
C15H20N2O4S

[ Molecular Weight ]:
324.39500

[ Flash Point ]:
240.6ºC

[ Exact Mass ]:
324.11400

[ PSA ]:
99.01000

[ LogP ]:
2.49358

Safety Information

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R20/21/22

[ Safety Phrases ]:
36/37-7/9

Related Compounds