5-ALA benzyl ester hydrochloride

Names

[ Name ]:
5-ALA benzyl ester hydrochloride

[Synonym ]:
5-Aminolevulinic acid benzyl ester hydrochloride
Benzyl 5-amino-4-oxopentanoate hydrochloride (1:1)
A-6130
Pentanoic acid, 5-amino-4-oxo-, phenylmethyl ester, hydrochloride (1:1)
5-Amino-4-oxopentanoic acid benzyl ester hydrochloride

Biological Activity

[Description]:

5-ALA benzyl ester hydrochloride (Benzyl-ALA hydrochloride) is a protoporphyrin precursor used as a photodetection agent. 5-ALA benzyl ester hydrochloride induces protoporphyrin IX (PPIX) accumulation in colon carcinoma cell lines[1][2].

[Related Catalog]:

Research Areas >> Cancer

[Target]

Human Endogenous Metabolite

[In Vitro]

5-ALA benzyl ester hydrochloride (Benzyl-ALA hydrochloride) (0.6-0.12 mM; 3 h) induces protoporphyrin IX (PPIX) accumulation in colon carcinoma cell lines SW480[2].

[In Vivo]

Reducing the dose of 5-ALA benzyl ester hydrochloride (31 mg/kg; i.v. ; 1 hours) results in a dose-dependent reduction in tumour porphyrin levels[3]. Animal Model: Female CBA/Gy mouse (CaNT tumour model)[3] Dosage: 31 mg/kg Administration: i.v. ; 1 hours Result: Reducing the dose of 5-ALA benzyl ester hydrochloride resulted in a dose-dependent reduction in the concentration of porphyrins accumulating in the CaNT tumour.

[References]

[1]. Hirschberg H, et al. ALA- and ALA-ester-mediated photodynamic therapy of human glioma spheroids. J Neurooncol. 2002 Mar;57(1):1-7.

[2]. Brunner H, et al. The effects of 5-aminolevulinic acid esters on protoporphyrin IX production in human adenocarcinoma cell lines. Photochem Photobiol. 2001 Nov;74(5):721-5.

[3]. Tunstall RG, et al. Porphyrin accumulation induced by 5-aminolaevulinic acid esters in tumour cells growing in vitro and in vivo. Br J Cancer. 2002 Jul 15;87(2):246-50.

Chemical & Physical Properties

[ Boiling Point ]:
385.1ºC at 760 mmHg

[ Molecular Formula ]:
C₁₂H₁₆ClNO₃

[ Molecular Weight ]:
257.713

[ Flash Point ]:
186.7ºC

[ Exact Mass ]:
257.081879

[ PSA ]:
69.39000

[ LogP ]:
2.54010

[ Vapour Pressure ]:
2.61E-06mmHg at 25°C

[ Storage condition ]:
-20°C

Safety Information

[ HS Code ]:
2922509090

Customs

[ HS Code ]: 2922509090

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%