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Kadsulignan N

Names

[ CAS No. ]:
163564-58-7

[ Name ]:
Kadsulignan N

[Synonym ]:
(1R,14S,15S,16R)-4,5,6,9,10,11-Hexamethoxy-15,16-dimethyl-17-oxatetracyclo[12.2.1.0.0]heptadeca-2,4,6,8,10,12-hexaene
5,8-Epoxydibenzo[a,c]cyclooctene, 5,6,7,8-tetrahydro-1,2,3,10,11,12-hexamethoxy-6,7-dimethyl-, (5R,6R,7S,8S)-

Biological Activity

[Description]:

Kadsulignan N, a natural product has anti-HIV activity (EC50: 43.56 μM). Kadsulignan N is also a COX-2 ligand (Ki: 72.24 nM)[1][2].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HIV
Research Areas >> Infection
Research Areas >> Inflammation/Immunology
Signaling Pathways >> Immunology/Inflammation >> COX

[Target]

COX-2


[In Vitro]

Kadsulignans N 对 COX-2 表现出较弱的抑制活性，IC50值为 600.54 μM[2]。

[References]

[1]. Gao XM, et al. Lignans from Kadsura angustifolia. J Nat Prod. 2008 Apr;71(4):558-63.  

[2]. Zhang XY, et al. Discovery of cyclooxygenase-2 inhibitors from Kadsura coccinea by affinity ultrafiltration mass spectrometry and the anti-inflammatory activity. Fitoterapia. 2021 Jun;151:104872.  

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
545.1±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C24H30O7

[ Molecular Weight ]:
430.491

[ Flash Point ]:
217.0±30.0 °C

[ Exact Mass ]:
430.199158

[ PSA ]:
64.61000

[ LogP ]:
4.24

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.535

Related Compounds