EGFR/HER2-IN-9

Names

[ CAS No. ]:
1637253-79-2

[ Name ]:
EGFR/HER2-IN-9

Biological Activity

[Description]:

EGFR/HER2-IN-9 (Compound 1) is an EGFR and HER2 inhibitor with IC50s of 3.2, 8.3 and 14 nM against EGFR, EGFR T790M and HER2, respectively[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> JAK/STAT Signaling >> EGFR
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR

[Target]

EGFR:3.2 nM (IC50)

EGFRT790M:8.3 nM (IC50)

HER2:14 nM (IC50)


[References]

[1]. Yingjun Zhang, et al. Amino quinazoline derivatives as well as salts and application method thereof. Patent CN104119350A.

Chemical & Physical Properties

[ Molecular Formula ]:
C25H25ClFN5O4

[ Molecular Weight ]:
513.95

Related Compounds