AF 64394
Names
[ CAS No. ]:
1637300-25-4
[ Name ]:
AF 64394
[Synonym ]:
N-(4-Chloro-2-isopropoxybenzyl)-5-phenyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
[1,2,4]Triazolo[1,5-a]pyrimidin-7-amine, N-[[4-chloro-2-(1-methylethoxy)phenyl]methyl]-5-phenyl-
Biological Activity
[Description]:
AF64394 is a GPR3 inverse agonist, with a pIC50 of 7.3.
[Related Catalog]:
[Target]
pIC50: 7.3 (GPR3)[1].
[In Vitro]
AF64394 is a GPR3 inverse agonist, with a pIC50 of 7.3. AF34394 and related compounds are only of modest potency and are relatively lipophilic (e.g., AF34394 clogP=5.2, LLE=2.1, and 14b clog P=3.1 and LLE=3.2) the series shows promising SAR and represents an excellent start point for further optimization[1].
[References]
[Related Small Molecules]
Captisol
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Cyclosporin A
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H2DCFDA
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0MPTP hydrochloride
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GW4869
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Etomoxir
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TD139
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Mitoquinone mesylate
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GSK2795039
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JC-1
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BAPTA-AM
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AP 20187
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Setanaxib (GKT137831)
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D-Luciferin
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Crotaline
Chemical & Physical Properties
[ Density]:
1.3±0.1 g/cm3
[ Molecular Formula ]:
C21H20ClN5O
[ Molecular Weight ]:
393.869
[ Exact Mass ]:
393.135651
[ LogP ]:
4.65
[ Index of Refraction ]:
1.661
[ Storage condition ]:
2-8℃