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AZITHROMYCIN-D3

Names

[ CAS No. ]:
163921-65-1

[ Name ]:
AZITHROMYCIN-D3

Biological Activity

[Description]:

Azithromycin-d3 (CP 62993-d3) is the deuterium labeled Azithromycin. Azithromycin (CP-62993) is a macrolide antibiotic useful for the treatment of a number of bacterial infections[1][2].

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Infection
Signaling Pathways >> Autophagy >> Autophagy
Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Menzel M, et al. Azithromycin augments rhinovirus-induced IFNβ via cytosolic MDA5 in experimental models of asthma exacerbation. Oncotarget. 2017 Mar 18.

[3]. Vandooren J, et al. Differential inhibition of activity, activation and gene expression of MMP-9 in THP-1 cells by azithromycin and minocycline versus bortezomib: A comparative study. PLoS One. 2017 Apr 3;12(4):e0174853.

Chemical & Physical Properties

[ Melting Point ]:
125-1290C

[ Molecular Formula ]:
C38H72N2O12

[ Molecular Weight ]:
748.98448

[ Storage condition ]:
-20°C Freezer, Under Inert Atmosphere

Related Compounds