Immepip, Dihydrobromide

Names

[ Name ]:
Immepip, Dihydrobromide

[Synonym ]:
Immepip dihydrobromide,4-(1H-Imidazol-4-ylmethyl)piperidinedihydrobromide
Immepip dihydrobromide
4-(1H-Imidazol-4-ylmethyl)piperidine dihydrobromide
Immepip,Dihydrobromide

Biological Activity

[Description]:

Immepip dihydrobromide is a H3 agonist. Immepip dihydrobromide can reduce cortical histamine release. Immepip dihydrobromide can be used for the research of neurological diseases[1].

[Related Catalog]:

Research Areas >> Neurological Disease

[In Vivo]

Immepip dihydrobromide (腹腔注射；5 mg/kg，10 mg/kg) 显著减少皮质组胺释放，且微弱地促进大鼠睡眠[1]。

Chemical & Physical Properties

[ Boiling Point ]:
430.2ºC at 760mmHg

[ Melting Point ]:
234-235 °C

[ Molecular Formula ]:
C₉H₁₇Br₂N₃

[ Molecular Weight ]:
327.05900

[ Flash Point ]:
214ºC

[ Exact Mass ]:
324.97900

[ PSA ]:
40.71000

[ LogP ]:
3.19680

[ Vapour Pressure ]:
6.32E-08mmHg at 25°C

[ Storage condition ]:
2-8°C

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Precautionary Statements ]:
P301 + P312 + P330

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R22

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2933990090

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Involvement of the H1 Histamine Receptor, p38 MAP Kinase, Myosin Light Chains Kinase, and Rho/ROCK in Histamine-Induced Endothelial Barrier Dysfunction.

Microcirculation 22 , 237-48, (2015)

The mechanisms by which histamine increases microvascular permeability remain poorly understood. We tested the hypothesis that H1 receptor activation disrupts the endothelial barrier and investigated ...

Histamine H3 receptor activation counteracts adenosine A2A receptor-mediated enhancement of depolarization-evoked [3H]-GABA release from rat globus pallidus synaptosomes.

ACS Chem. Neurosci. 5(8) , 637-45, (2014)

High levels of histamine H3 receptors (H3Rs) are found in the globus pallidus (GP), a neuronal nucleus in the basal ganglia involved in the control of motor behavior. By using rat GP isolated nerve te...

Development of time-resolved fluorescent based [EU]-GTP binding assay for selection of human Histamine 3 receptor antagonists/inverse agonist: a potential target for Alzheimer's treatment.

Ann Neurosci 19 , 71-5, (2014)

The histamine H3 receptor is an attractive G protein-coupled receptor drug target that regulates neurotransmission in the central nervous system and plays a crucial role in cognitive and homeostatic f...