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Aldicarb (sulfone)

Names

[ CAS No. ]:
1646-88-4

[ Name ]:
Aldicarb (sulfone)

[Synonym ]:
2-methyl-2-(methylsulfonyl)propanal O-[(methylamino)carbonyl]oxime
(5Ξ)-7,7-dimethyl-8,8-dioxo-4-oxa-8λ6-thia-2,5-diazanon-5-en-3-one
[(E)-(2-methyl-2-methylsulfonylpropylidene)amino] N-methylcarbamate
MFCD00041804
EINECS 216-710-0
Aldicarb Sulfone
Propanal, 2-methyl-2-(methylsulfonyl)-, O-[(methylamino)carbonyl]oxime
aldoxycarb
(EZ)-2-mesyl-2-methylpropionaldehyde O-methylcarbamoyloxime
7,7-Dimethyl-4-oxa-8-thia-2,5-diazanon-5-en-3-one 8,8-dioxide
Aldicarb (sulfone)

Biological Activity

[Description]:

Aldicarb sulfone(Temik sulfone) is a carbamate insecticide; is a cholinesterase inhibitor which prevents the breakdown of acetylcholine in the synapse.

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> AChE
Research Areas >> Others

[Related Small Molecules]

Galantamine | Choline glycerophosphate | benzethonium chloride | Malathion | (-)-Huperzine A | pyridostigmine bromide | Scopoletin | Tacrine hydrochloride hydrate | Huperzine A | Epiberberine chloride | Protriptyline hydrochloride | Imperatorin | Itopride hydrochloride | Enzacamene | Corydaline

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Melting Point ]:
132-135ºC

[ Molecular Formula ]:
C7H14N2O4S

[ Molecular Weight ]:
222.262

[ Exact Mass ]:
222.067429

[ PSA ]:
93.21000

[ LogP ]:
-0.57

[ Index of Refraction ]:
1.495

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UE2080000
CHEMICAL NAME :
Propionaldehyde, 2-methyl-2-(methylsulfonyl)-, O-(methylcarbamoyl)oxime
CAS REGISTRY NUMBER :
1646-88-4
LAST UPDATED :
199710
DATA ITEMS CITED :
10
MOLECULAR FORMULA :
C7-H14-N2-O4-S
MOLECULAR WEIGHT :
222.29
WISWESSER LINE NOTATION :
WS1&X1&1&1UNN1&VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
20 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460) Volume(issue)/page/year: FYI-OTS-0885-0443
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
140 mg/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,18,1991
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SPEADM Special Publication of the Entomological Society of America. (4603 Calvert Rd., College Park, MD 20740) Volume(issue)/page/year: 78-1,61,1978
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
21 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460) Volume(issue)/page/year: FYI-OTS-0885-0443
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
14900 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460) Volume(issue)/page/year: FYI-OTS-0885-0443
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094) Volume(issue)/page/year: -,C14,1989
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - duck
DOSE/DURATION :
33500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,18,1991

Safety Information

[ Symbol ]:

GHS06, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H300-H310-H330-H400

[ Precautionary Statements ]:
P260-P264-P273-P280-P284-P302 + P350

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
T+: Very toxic;

[ Risk Phrases ]:
24-26/28

[ Safety Phrases ]:
S28;S45;S36/S37

[ RIDADR ]:
UN 2757

[ RTECS ]:
UE2080000

[ Packaging Group ]:
I

[ Hazard Class ]:
6.1(a)

[ HS Code ]:
2930909052

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2930909052

[ Summary ]:
2930909052 (e)-2-methyl-2-(methylsulfonyl)propanal o-methylcarbamoyl oxime。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:0.0%。MFN tarrif:6.5%。general tariff:30.0%

Articles

Determination of pesticides in soy-based infant formula using liquid chromatography with electrospray ionization tandem mass spectrometry.

J. AOAC Int. 89(1) , 214-24, (2006)

A sensitive method using liquid chromatography with electrospray ionization tandem mass spectrometry (LC/ESI-MS/MS) was developed and validated to quantify and confirm 13 pesticides, including aldicar...

Persistence and metabolism of aldicarb in fresh potatoes.

Bull. Environ. Contam. Toxicol. 32(3) , 274-81, (1984)

[Gas chromatographic analysis of aldicarb and its metabolites in urine].

Zhonghua Yu Fang Yi Xue Za Zhi 25(3) , 136-8, (1991)

A method is described for the analysis of aldicarb and its metabolites in urine by GC/FPD. The sample was concentrated with activated charcoal-Florisil column chromatography, eluted by dichloromethane...


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Related Compounds