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UNC-2170

Names

[ CAS No. ]:
1648707-58-7

[ Name ]:
UNC-2170

[Synonym ]:
3-Bromo-N-[3-(Tert-Butylamino)propyl]benzamide
3-Bromo-N-{3-[(2-methyl-2-propanyl)amino]propyl}benzamide
Benzamide, 3-bromo-N-[3-[(1,1-dimethylethyl)amino]propyl]-

Biological Activity

[Description]:

UNC-2170 is a functionally active, fragment-like ligand for 53BP1 (IC50=29 µM; Kd=22 µM). UNC-2170 shows at least 17-fold selectivity for 53BP1 as compared to nine other methyl-lysine (Kme) reader proteins. 53BP1 is a Kme binding protein that plays a central role in DNA Damage Repair (DDR) pathways and is recruited to sites of double-strand breaks (DSB)[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[In Vitro]

UNC-2170 (500 µM) results in a significant increase in soluble 53BP1 as compared to untreated lysates or lysates treated with UNC2892, the negative control compound. UNC-2170 (30-100 µM; naive splenocytes cultured with LPS and IL-4 for 3.5 days) clearly phenocopies the reduction in CSR seen in 53BP1 mutant B cells[1].

[References]

[1]. Perfetti MT, et al. Identification of a fragment-like small molecule ligand for the methyl-lysine binding protein, 53BP1. ACS Chem Biol. 2015;10(4):1072-1081.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
419.6±30.0 °C at 760 mmHg

[ Molecular Formula ]:
C14H21BrN2O

[ Molecular Weight ]:
313.233

[ Flash Point ]:
207.6±24.6 °C

[ Exact Mass ]:
312.083710

[ LogP ]:
2.99

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.534

Related Compounds