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mutant IDH1 inhibitor VVS

Names

[ CAS No. ]:
1648909-73-2

[ Name ]:
mutant IDH1 inhibitor VVS

[Synonym ]:
2,6-Bis((1H-Imidazol-1-yl)methyl)-4-(2,4,4-trimethylpentan-2-yl)phenol
2,6-Bis(1H-imidazol-1-ylmethyl)-4-(2,4,4-trimethyl-2-pentanyl)phenol
Phenol, 2,6-bis(1H-imidazol-1-ylmethyl)-4-(1,1,3,3-tetramethylbutyl)-
2,6-Bis(1h-Imidazol-1-Ylmethyl)-4-(2,4,4-Trimethylpentan-2-Yl)phenol
Bis-Imidazole phenol IDH1 inhibitor

Biological Activity

[Description]:

mutant IDH1 inhibitor VVS is a potent, selective mutant IDH1 inhibitor with nanomolar potency against both IDH1 R132H and IDH1 R132C, efficiently suppresses the cell-based production of D-2-HG in an HEK293 mutant embryonic kidney cell line.

[References]

References 1. Deng G, et al. J Biol Chem. 2015 Jan 9;290(2):762-74. 2. Ma T, et al. J Med Chem. 2018 Jun 18. doi: 10.1021/acs.jmedchem.8b00159. View Related Products by Target Isocitrate Dehydrogenase (IDH)

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
549.7±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C22H30N4O

[ Molecular Weight ]:
366.500

[ Flash Point ]:
286.2±28.7 °C

[ Exact Mass ]:
366.241974

[ LogP ]:
3.41

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.577

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Related Compounds