ML352

Names

[ Name ]:
ML352

[Synonym ]:
N-[(3-Isopropyl-1,2-oxazol-5-yl)methyl]-4-methoxy-3-[(1-methyl-4-piperidinyl)oxy]benzamide
MFCD28975158
Benzamide, 4-methoxy-N-[[3-(1-methylethyl)-5-isoxazolyl]methyl]-3-[(1-methyl-4-piperidinyl)oxy]-

Biological Activity

[Description]:

ML352 is a noncompetitive inhibitor of the presynaptic choline transporter (CHT) with Kivalues of 92 and 166 nM for HEK293 cells expressing human CHT and mouse forebrain synaptosomes, respectively[1].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> AChE

[References]

[1]. Ennis EA, Wright J, Retzlaff CL, McManus OB, Lin Z, Huang X, et al. Identification and characterization of ML352: a novel, noncompetitive inhibitor of the presynaptic choline transporter. ACS Chem Neurosci. 2015 Mar 18;6(3):417-27.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
538.1±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₁H₂₉N₃O₄

[ Molecular Weight ]:
387.473

[ Flash Point ]:
279.2±30.1 °C

[ Exact Mass ]:
387.215820

[ LogP ]:
2.23

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.546