cis-Epoxysuccinic acid

Names

[ Name ]:
cis-Epoxysuccinic acid

[Synonym ]:
MFCD00191645
EINECS 240-604-3
CIS-EPOXYSUCCINIC ACID
cis-2,3-Oxiranedicarboxylic Acid

Biological Activity

[Description]:

cis-Epoxysuccinic acid is a succinate receptor (SUCNR1/GPR91) agonist. cis-Epoxysuccinic acid inhibits cAMP levels with an EC50 value of 2.7 µM. cis-Epoxysuccinic acid can be used for the research of cardiovascular system[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

[In Vitro]

cis-Epoxysuccinic acid (1-100 μM; 10 min) affects cAMP levels of HEK293 cells[1]. cis-Epoxysuccinic acid (0.1 μM-100 mM; 1 h) agonists SUCNR1 pathways without affects succinate dehydrogenase[1]. Cell Viability Assay[1] Cell Line: HEK293 cells Concentration: 1, 10 and 100 μM Incubation Time: 10 min Result: Inhibited cAMP levels with an EC50 value of 2.7 µM. Cell Viability Assay[1] Cell Line: HEK293 cells Concentration: 0.1 μM-100 mM Incubation Time: 1 hour Result: Induced the Gq pathway, recruited arrestin 3 and elicited [Ca2+]i mobilization with EC50 values of 42, 74 and 191 µM, respectively.

[In Vivo]

cis-Epoxysuccinic acid (1 mg/kg; i.v. once) has an effect on the blood pressure of rats[1]. Animal Model: Male Wistar rats[1] Dosage: 1 mg/kg Administration: Intravenous injection; 1 mg/kg once Result: Showed in vivo activity and increased blood pressure after injection.

[References]

[1]. Geubelle P, et al. Identification and pharmacological characterization of succinate receptor agonists. Br J Pharmacol. 2017 May;174(9):796-808.

Chemical & Physical Properties

[ Density]:
1.9±0.1 g/cm3

[ Boiling Point ]:
467.5±45.0 °C at 760 mmHg

[ Melting Point ]:
148-149 °C

[ Molecular Formula ]:
C₄H₄O₅

[ Molecular Weight ]:
132.072

[ Flash Point ]:
215.7±22.2 °C

[ Exact Mass ]:
132.005875

[ PSA ]:
87.13000

[ LogP ]:
-1.25

[ Vapour Pressure ]:
0.0±2.5 mmHg at 25°C

[ Index of Refraction ]:
1.585

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
C: Corrosive;

[ Risk Phrases ]:
34-2

[ Safety Phrases ]:
S45-S36/37/39-S26

[ HS Code ]:
2918990090

Customs

[ HS Code ]: 2918990090

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%